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Stereoselective syntheses of (+/-)-epibatidine analogues
Yong-Hyun Kim1, Do-Youn Won, Chang-Young Oh
1College of Pharmacy, SungKyunKwan University, Suwon, Korea.
Archives of Pharmacal Research
|March 12, 2002
Abstract:
Stereoselective syntheses of (+/-)-epibatidine analogues 2, which contain the 8-azabicyclo [3.2.1]octane ring system, were achieved by using palladium-catalyzed cross-coupling reaction from 4 and the analgesic activity was tested by Mouse writhing antinociceptive assay.