Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bones, groans and blasts.

D Shanks1, R Linke, B Saxon

  • 1Department of Oncology, Women's and Children's Hospital, Adelaide, South Australia, Australia.

Journal of Paediatrics and Child Health
|March 12, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A probabilistic-deterministic approach for assessing climate change effects on infection risks downstream of sewage emissions from CSOs.

Water research·2023
Same author

Automated detection of poor-quality data: case studies in healthcare.

Scientific reports·2021
Same author

ATLAS trial of adjuvant axitinib in patients with renal cell carcinoma: subgroup analyses with focus on axitinib dosing and racial groups.

ESMO open·2021
Same author

Pancreas size and exocrine function is decreased in young children with recent-onset Type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2019
Same author

Axitinib versus placebo as an adjuvant treatment of renal cell carcinoma: results from the phase III, randomized ATLAS trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2018
Same author

Junior doctors' perspectives on transfusion education in Australia.

Vox sanguinis·2018
Same journal

Impact of Access to Pasteurised Donor Human Milk on Rates of Necrotising Enterocolitis in Neonatal Units in Australia: A Cohort Study.

Journal of paediatrics and child health·2026
Same journal

Prescribing Cascade in Children With Chronic Complex Diseases: An Argument for De-Escalation and Medication Review, a Case Report.

Journal of paediatrics and child health·2026
Same journal

Post-COVID-19 Autonomic Dysfunction in an Adolescent: Ogilvie Syndrome With Acute Urinary Retention.

Journal of paediatrics and child health·2026
Same journal

Serial Ultrasonography-Guided Management of Primary Sternal Osteomyelitis With Abscess Formation in a Child: A Case Report.

Journal of paediatrics and child health·2026
Same journal

"Raccoon Eyes": A Rare Presentation of Paediatric Scrub Typhus.

Journal of paediatrics and child health·2026
Same journal

Definitions and Severity/Risk Prediction Tools for Bronchopulmonary Dysplasia: A Scoping Review.

Journal of paediatrics and child health·2026
See all related articles

A 14-year-old girl experienced severe gastrointestinal issues from hypercalcemia. Doctors diagnosed acute lymphoblastic leukemia despite initial normal blood tests, and she responded well to treatment.

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Medical Imaging

Background:

  • Hypercalcemia can present with non-specific gastrointestinal symptoms in adolescents.
  • Osteolytic lesions on imaging, coupled with normal parathyroid hormone levels, suggest underlying malignancy.
  • Acute lymphoblastic leukemia (ALL) can manifest with diverse symptoms, including those mimicking other conditions.

Observation:

  • A 14-year-old female presented with acute gastrointestinal distress attributed to hypercalcemia.
  • Chest X-ray identified osteolytic rib lesions, prompting further investigation for malignancy.
  • Initial peripheral blood smear lacked blast cells, complicating the diagnostic process.

Findings:

  • Bone marrow biopsy definitively diagnosed acute lymphoblastic leukemia (ALL).

Related Experiment Videos

  • The patient's hypercalcemia and osteolytic lesions were consequences of the leukemia.
  • Treatment with pamidronate and chemotherapy led to a positive clinical response.

    • Implications:

    • This case highlights the importance of considering leukemia in adolescents with hypercalcemia and osteolytic bone lesions, even with normal initial blood work.
    • Early and accurate diagnosis is crucial for effective management of pediatric leukemia.
    • Multimodal treatment approaches, including bisphosphonates and chemotherapy, are effective in managing leukemia-associated complications.