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Infection in xenotransplantation.

J A Fishman1

  • 1Infectious Disease and Transplantation Units, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA. jfishman@partners.org

Journal of Cardiac Surgery
|March 12, 2002
PubMed
Summary
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Xenotransplantation offers hope for organ failure but carries risks of animal-to-human pathogen spread (xenosis). Research is crucial to ensure safety for recipients and the public.

Area of Science:

  • Transplantation Immunology
  • Infectious Diseases
  • Microbiology

Background:

  • Xenotransplantation is a potential solution for end-stage organ failure.
  • Interspecies transplantation raises concerns about animal-derived pathogen transmission (xenosis).
  • The immunocompromised state of recipients can alter pathogen behavior and complicate diagnosis.

Purpose of the Study:

  • To explore the potential risks and benefits of xenotransplantation.
  • To address concerns regarding xenosis and pathogen activation, particularly retroviruses.
  • To outline the need for safety protocols in xenotransplantation.

Main Methods:

  • Review of transplantation immunology advancements.
  • Analysis of potential pathogen risks, including latent virus activation.

Related Experiment Videos

  • Consideration of strategies for pathogen exclusion from donor animals.
  • Evaluation of xenotransplantation for treating chronic infections.

    • Main Results:

    • Xenotransplantation presents a viable therapeutic option for organ failure.
    • Xenosis is a significant risk, potentially complicated by altered pathogen behavior in recipients.
    • Latent viruses, such as retroviruses, pose a particular concern.
    • Prospective pathogen exclusion from donor herds is feasible, drawing from allogeneic transplantation experience.

    Conclusions:

    • Further research into retroviral activation and pathogen behavior in xenotransplantation is essential.
    • Xenotransplantation may offer therapeutic benefits beyond organ replacement, including treating chronic infections.
    • Development of robust clinical protocols is critical to ensure recipient and public safety.