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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

1.1K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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HCV-Positive Donor Organs in Solid Organ Transplantation: "Mind the Gap!"

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Prolonged Survival Following Pig-to-Primate Liver Xenotransplantation Utilizing Exogenous Coagulation Factors and Costimulation Blockade.

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Metrics and Data Analysis in Transplantation: Quality Improvement via Transparency.

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Zika Virus in Transplantation: Emerging Infection and Opportunities.

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Advancing Transplant Care in AIDS: Encouraging Innovation in Transplantation.

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Updated: Mar 8, 2026

Murine Full-thickness Skin Transplantation
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Murine Full-thickness Skin Transplantation

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Infection in Organ Transplantation.

J A Fishman1

  • 1Transplant Infectious Disease and Immunocompromised Host Program and MGH Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|January 25, 2017
PubMed
Summary
This summary is machine-generated.

Managing infectious diseases is crucial for successful organ transplantation outcomes. Early diagnosis and targeted therapies, considering patient factors and immune suppression, improve graft survival and patient health.

Keywords:
clinical research/practicecomplication: infectiousfungalimmunosuppression/immune modulationinfection and infectious agentsinfectious diseasemicrobiomicsorgan transplantation in generalviral

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Area of Science:

  • Transplant Infectious Diseases
  • Immunology
  • Microbiology

Background:

  • Infectious diseases significantly impact outcomes in organ transplantation.
  • Risk is influenced by patient exposures and immune suppression levels.
  • Drug toxicity and interactions with immunosuppressants are common challenges.

Purpose of the Study:

  • To highlight the importance of infectious disease management in organ transplantation.
  • To outline strategies for diagnosis and therapy optimization.
  • To identify current challenges and future research directions.

Main Methods:

  • Developing differential diagnoses based on exposure, immunosuppression, and prophylaxis.
  • Utilizing quantitative molecular microbial assays.
  • Exploring pathogen-specific immunity and microbiome interactions.

Main Results:

  • Advanced antimicrobial therapies and molecular assays improve care.
  • Understanding host-pathogen interactions is evolving.
  • The role of infection in alloimmunity requires further investigation.

Conclusions:

  • Optimizing infectious disease prevention, diagnosis, and management is vital for transplant success.
  • Addressing challenges like antimicrobial resistance and donor screening is essential.
  • Transplant infectious disease research remains a critical area.