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Related Experiment Videos

The human obesity gene map: the 2001 update.

Tuomo Rankinen1, Louis Pérusse, S John Weisnagel

  • 1Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808-4124, USA. rankint@mhs.pbrc.edu

Obesity Research
|March 12, 2002
PubMed
Summary

This eighth update of the human obesity gene map reviews evidence linking genes to obesity. Over 250 genes, markers, and regions are now associated with obesity phenotypes, highlighting genetic factors.

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Area of Science:

  • Genetics
  • Obesity Research
  • Genomics

Background:

  • Obesity is a complex trait with significant genetic underpinnings.
  • Understanding the genetic architecture of obesity is crucial for developing effective interventions.
  • Previous gene maps have identified numerous loci associated with obesity.

Purpose of the Study:

  • To provide an updated comprehensive map of genes and loci associated with human obesity.
  • To review and integrate evidence from various genetic studies, including single-gene mutations, Mendelian disorders, quantitative trait loci (QTLs), and association studies.
  • To track the progress in identifying genetic factors contributing to obesity.

Main Methods:

  • Systematic review of published literature up to October 2001.

Related Experiment Videos

  • Inclusion of data from human and rodent obesity cases.
  • Analysis of Mendelian disorders with obesity phenotypes.
  • Review of quantitative trait loci (QTLs) from genome-wide scans and animal models.
  • Examination of association and linkage studies with candidate genes and markers.

    • Main Results:

    • Incorporation of human obesity cases linked to mutations in six genes.
    • Mapping of 25 Mendelian disorders with obesity as a clinical feature.
    • Identification of 165 QTLs from animal models.
    • 174 studies reported positive associations with 58 candidate genes.
    • 59 loci linked to obesity indicators through genomic scans and linkage studies.
    • 54 new loci added in the past year, bringing the total associated/linked loci to over 250.
    • Putative obesity-related loci found on all chromosomes except Y.

    Conclusions:

    • The human obesity gene map continues to expand, with a significant increase in identified genetic loci.
    • Genetic factors contributing to obesity are distributed across the genome.
    • The growing number of identified genes and loci underscores the complex genetic basis of obesity.
    • The increasing number of studies, including negative findings, reflects the ongoing research efforts in this field.