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[Inflammatory pseudotumors of the lung with severe course]

F Girard1, M Kambouchner, S Maugendre

  • 1Fédération des maladies respiratoires et thoraciques, Hôpital Avicenne, CHU Bobigny, 93009 Bobigny. frederic.girard@avc.ap-hop-paris.fr

Revue Des Maladies Respiratoires
|March 13, 2002
PubMed

Insights

Pulmonary inflammatory pseudotumors, typically benign, can exhibit aggressive behavior. Microscopic features like increased cellularity and bizarre giant cells may indicate poor prognosis, necessitating aggressive surgical management.

Area of Science:

  • Pulmonology
  • Pathology
  • Oncology

Background:

  • Pulmonary inflammatory pseudotumors (PIPs) are rare, typically solitary lesions of uncertain origin with a generally favorable prognosis.
  • This study investigates two severe PIP cases exhibiting aggressive characteristics.

Observation:

  • Cases presented with mediastinal invasion, local recurrence, and extrathoracic spread.
  • One patient experienced a fatal outcome, highlighting the potential for severe disease progression.

Findings:

  • Specific microscopic features, including increased cellularity, nuclear pleomorphism, mitotic activity, necrosis, giant cells, and vascular invasion, were noted.
  • These features may serve as prognostic indicators for aggressive PIP behavior.

Implications:

  • Incomplete surgical resection appears to be a significant risk factor for recurrence.
  • While immunosuppressive therapy and radiotherapy were ineffective, high-dose corticosteroids showed potential in slowing disease progression.

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