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Determination of lactic acid level in systemic liquids in children with progressive encephalopathies
Elzbieta Marszał1, Katarzyna Wojaczyńska-Stanek, Jerzy Pietruszewski
1Department of Pediatric Neurology, Silesian Medical University, Katowice, Poland.
Insights
Children with progressive encephalopathies (PE) have higher lactic acid levels in their serum and cerebrospinal fluid (CSF) compared to those with non-progressive encephalopathies. Clinical status did not correlate with these lactate levels in PE patients.
Area of Science:
- Pediatric Neurology
- Biochemistry
- Neuroscience
Background:
- Investigated lactic acid concentrations in body fluids of children with various encephalopathies.
- Compared progressive encephalopathies (PE) to non-progressive (NPE) and NPE with epilepsy (NPEE).
Purpose of the Study:
- Determine differences in serum and CSF lactic acid between PE, NPE, and NPEE.
- Assess correlation between clinical status and lactate levels in PE patients.
Main Methods:
- Analyzed serum and cerebrospinal fluid lactate concentrations.
- Included 138 children (8 months–15 years) treated between 1995–1997.
Main Results:
- Children with PE exhibited higher serum and CSF lactate concentrations than NPE patients.
- No correlation was found between clinical symptom severity and lactate levels in PE.
Conclusions:
- Progressive encephalopathies are associated with elevated serum and CSF lactate levels compared to static encephalopathies.
Background:
This article reports the results of research into the activities of lactic acid concentrations in the body fluids of children with progressive encephalopathies (PE) in comparison to patients with non-progressive encephalopathies (NPE) and those with non-progressive encephalopathies with concomitant epilepsy (NPEE). The study was designed to determine whether there is difference between the serum and CSF lactic acid concentrations in children with progressive encephalopathies (PE), static (non-progressive) encephalopathies (NPE) and non progressive encephalopathies with concomitant epilepsy (NPEE), and whether the clinical status correlates with the concentration of these biochemical markers in children with PE.
Material/Methods:
The assessment involved 138 children of both sexes, whose age ranged between 8 months and 15 years, diagnosed and treated in the Neurology Department at the Pediatric Clinic of the Silesian Medical Academy in Katowice between 1995 and 1997. Lactate concentrations were determined in serum and cerebro-spinal fluid and analyzed statistically.
Results:
The findings showed higher serum and CSF concentrations in children with PE than in patients who manifested non-progressive forms of encephalopathy. The degree of clinical symptom aggravation in PE children was likewise analyzed and compared to the values of lactate concentrations in body fluids; however, no correlation was found between these parameters.
Conclusions:
Children with progressive encephalopathies present higher lactate concentrations in serum and cerebrospinal fluid than patients with static (non-progressive) encephalopathy.