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Molecular BKology: the study of splicing and dicing
Matthew Fury1, Steven O Marx, Andrew R Marks
1Center for Molecular Cardiology, Department of Pharmacology, and Division of Cardiology, New York, NY 10032, USA.
Science'S STKE : Signal Transduction Knowledge Environment
|March 14, 2002
Abstract:
The activity of ion channels is regulated by several different mechanisms. Studies have been undertaken to determine how the large-conductance Ca(2+)-sensitive K(+) channel (the BK channel) is regulated. Fury et al. discuss how the presence or absence of alternatively spliced regions in the BK channel alpha subunit can act as a molecular switch by which different kinases activate the BK channel.