Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitogen-activated protein kinases.

Saman Arbabi1, Ronald V. Maier

  • 1University of Michigan (SA), the Department of Surgery, Ann Arbor, MI; and the University of Washington (RVM), the Department of Surgery, Seattle, WA.

Critical Care Medicine
|March 14, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Initial management of patients with burns and combined injuries for acute care surgeons: What you need to know.

The journal of trauma and acute care surgery·2025
Same author

Improving post-injury follow-up survey response: incorporating automated modalities.

Injury epidemiology·2024
Same author

Severity of Inhalation Injury and Risk of Nosocomial Pneumonia: A Retrospective Cohort Study.

Chest·2024
Same author

Early Fluid Is Less Fluid: Comparing Early Versus Late ICU Resuscitation in Severely Injured Trauma Patients.

Critical care explorations·2024
Same author

Improving Post-Injury Follow-up Survey Response: Incorporating Automated Modalities.

Research square·2024
Same author

Identifying Common Data Elements to Achieve Injury-related Health Equity Across the Lifespan: A Consensus-Driven Approach.

Health equity·2024
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Attracting Emergency Medicine Graduates to Surgical Critical Care Training Programs.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Beyond a Snapshot: Tracking Family Prognostic Expectations in the ICU.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure: Beware of Potential Confounders.

Critical care medicine·2026
See all related articles

Understanding mitogen-activated protein kinase (MAPK) pathways is key for identifying patients at risk of systemic inflammatory response syndrome. Targeting these pathways could improve outcomes, but requires a nuanced approach due to network complexity.

Area of Science:

  • Molecular biology
  • Cellular signaling
  • Immunology

Background:

  • Intracellular signal transduction pathways, including the mitogen-activated protein kinase (MAPK) family, regulate cellular processes.
  • Dysregulated MAPK pathways are implicated in inflammatory responses leading to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS).

Purpose of the Study:

  • To explore the role of MAPK pathways in SIRS/MODS.
  • To investigate the potential of targeting MAPK pathways for therapeutic benefit.
  • To address the challenges in manipulating these complex signaling networks.

Main Methods:

  • Analysis of intracellular signal transduction pathways.
  • Investigation of MAPK family activation status.

Related Experiment Videos

  • Exploration of network dynamics in inflammatory responses.

    • Main Results:

    • MAPK pathways are critical regulators of cellular control.
    • Identifying MAPK activation status may predict SIRS/MODS risk.
    • Complex MAPK networks pose challenges for targeted inhibition or activation.

    Conclusions:

    • Elucidating MAPK pathway activation is crucial for identifying at-risk patients.
    • Targeting MAPK pathways holds therapeutic potential for SIRS/MODS.
    • Further research is needed to understand network assembly for precise therapeutic strategies.