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Recombinant allergens/allergen standardization.

H Løwenstein1, J N Larsen

  • 1ALK-Abelló A/S, Bøge Allé 6-8, 2970 Hørsholm, Denmark. hl@dk.alk-abello.com

Current Allergy and Asthma Reports
|March 15, 2002
PubMed
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Recombinant allergens offer a standardized approach for allergy diagnostics and treatment. Using a major recombinant allergen as a standard improves diagnostic sensitivity and therapeutic efficacy for allergic patients.

Area of Science:

  • Allergen immunotherapy
  • Molecular allergology
  • Biotechnology

Background:

  • Allergen extracts contain complex mixtures of isoallergens and other molecules.
  • Diagnostic sensitivity and treatment efficacy in allergy depend on major allergen concentration.
  • Standardization of allergen products is crucial for reliable allergy diagnostics and therapy.

Purpose of the Study:

  • To explore the use of recombinant allergens for standardizing allergy diagnostic and therapeutic products.
  • To evaluate the role of recombinant antibodies in allergen standardization.
  • To highlight the necessity of biological potency assessment alongside standardization.

Main Methods:

  • Utilizing genetically engineered recombinant allergens as standards.

Related Experiment Videos

  • Employing monospecific, monoclonal, or recombinant antibodies for standardization reagents.
  • Supplementing standardization with biological potency assessment.

    • Main Results:

    • Recombinant allergens can serve as reliable standards for allergen products.
    • Standardization using recombinant major allergens enhances diagnostic sensitivity and treatment efficacy.
    • Biological potency assessment remains essential due to variations in allergenic activity.

    Conclusions:

    • Recombinant allergens provide a valuable tool for standardizing allergen extracts and products.
    • Standardization with recombinant allergens, complemented by biological potency testing, optimizes allergy diagnostics and treatment.
    • Further development of recombinant antibodies aids in precise allergen characterization and standardization.