Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A view to a kill: signals triggering cytotoxicity.

Julie Y Djeu1, Kun Jiang, Sheng Wei

  • 1Immunology Program, H. Lee Moffitt Cancer Center, University of South Florida College of Medicine, Tampa, Florida 33612, USA. djeu@moffitt.usf.edu

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|March 16, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SIRPα modulates microglial efferocytosis and neuroinflammation following experimental subarachnoid hemorrhage via the SHP1/STAT6 axis.

Journal of neuroinflammation·2025
Same author

Nanoscale high-entropy surface engineering promotes selective glycerol electro-oxidation to glycerate at high current density.

Nature nanotechnology·2025
Same author

An I<sub>2</sub>/amine synergistic catalysis enables 2,2'-bipyridine synthesis from oxime esters and enals.

Organic & biomolecular chemistry·2025
Same author

Interbacterial warfare in the human gut: insights from Bacteroidales' perspective.

Gut microbes·2025
Same author

Grid-Centric Traffic Scenario Perception for Autonomous Driving: A Comprehensive Review.

IEEE transactions on neural networks and learning systems·2025
Same author

Clinical characteristics and risk factors of <i>Clostridioides difficile</i> infection in children with diarrhoea.

Frontiers in pediatrics·2025

Natural killer (NK) cells and CTLs use similar cell-killing processes but distinct receptors. A common signaling pathway involving Syk/Zap70, PI3K, and ERK activates NK cell cytotoxicity against tumor targets.

Area of Science:

  • Immunology
  • Cellular Biology
  • Cancer Research

Background:

  • Tumor immunity relies on effector lymphocytes like NK cells and CTLs to eliminate malignant cells.
  • NK cells and CTLs employ similar cytotoxic mechanisms but are activated via separate antigen receptors.
  • NK cells utilize NKG2, KIR, and NCR receptor families for cytotoxicity.

Purpose of the Study:

  • To present a unifying concept for a common signaling pathway that regulates lytic function in NK cells.
  • To elucidate the molecular cascade responsible for NK cell-mediated cytotoxicity.

Main Methods:

  • Review of existing literature on NK cell receptors and signaling pathways.
  • Analysis of signal transduction cascades involved in lymphocyte effector functions.

Related Experiment Videos

Main Results:

  • A specific signaling cascade, Syk/Zap70 → PI3K → Rac → PAK → MEK → ERK, is identified as crucial for lytic function.
  • This pathway is triggered upon target cell recognition by NK cells.

Conclusions:

  • The identified signaling cascade provides a unified mechanism for NK cell-mediated cytotoxicity.
  • Activation of this pathway mobilizes cytotoxic granules (containing perforin and granzyme B) towards target cells, facilitating tumor cell destruction.