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An I2/amine synergistic catalysis enables 2,2'-bipyridine synthesis from oxime esters and enals
Xiao-Kun Jin1, Jia-Hao Zhou1, Han-Ying Zeng1
1Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. kjiang@swu.edu.cn.
Abstract:
A synergistic I2/secondary amine catalysis has been developed for the modular assembly of 2,2'-bipyridines, employing oxime esters and enals as readily available starting materials. This method demonstrates a good substrate scope and functional group tolerance and can easily afford a series of structurally new 2,2'-bipyridines in moderate to good yields.
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