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SSRI sexual dysfunction: a female perspective.

Paula L Hensley1, H George Nurnberg

  • 1Department of Psychiatry, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.

Journal of Sex & Marital Therapy
|March 20, 2002
PubMed
Summary
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Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed, but can cause sexual dysfunction. While men report higher rates, women experience more severe SSRI-related sexual side effects, with sildenafil offering a potential treatment.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Women's Health

Background:

  • Women have higher depression rates than men.
  • Selective serotonin reuptake inhibitors (SSRIs) treat various conditions, some more prevalent in women.
  • SSRIs are associated with sexual side effects, impacting treatment adherence and quality of life.

Purpose of the Study:

  • To review the epidemiology of sexual dysfunction associated with SSRI use.
  • To discuss the prevalence and severity of sexual side effects in women taking SSRIs.
  • To explore sildenafil as a potential treatment for SSRI-induced sexual dysfunction.

Main Methods:

  • Literature review of epidemiological studies on SSRI-induced sexual dysfunction.
  • Analysis of reported sexual side effect rates and severity in men and women.

Related Experiment Videos

  • Examination of clinical data regarding sildenafil efficacy for sexual dysfunction.

    • Main Results:

    • Women experience depression at 2-3 times the rate of men.
    • While men report higher incidence of sexual side effects from SSRIs, women report greater severity.
    • Sildenafil is presented as a treatment option for SSRI-induced sexual dysfunction.

    Conclusions:

    • SSRI-induced sexual dysfunction is a significant concern, particularly for women.
    • The severity of sexual dysfunction in women warrants further investigation and targeted treatment strategies.
    • Sildenafil demonstrates potential as a therapeutic intervention for managing SSRI-related sexual dysfunction in women.