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Molecular steps of tumor necrosis factor receptor-mediated apoptosis
1Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine 92697, USA. sgupta@uci.edu
Current Molecular Medicine
|March 20, 2002
Abstract:
Until recently it was believed that TNF-induced apoptosis is mediated exclusively by TNF-RI because TNF-RII lacks death domain. However, it has been demonstrated that TNF-RII enhances TNF-RI-mediated apoptosis. In this review, I have discussed the evidence and mechanisms by which TNF-RII regulates TNF-alpha-induced apoptosis. A role of RIP is emphasized and novel mechanisms of FLIP-mediated inhibition of apoptosis are discussed. In addition, various mechanisms of TNF-induced activation of mitochondrial pathway of apoptosis have been reviewed.