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Novel drugs for treating asthma.

T T Hansel1, P J Barnes

  • 1National Heart and Lung Institute (NHLI) Clinical Studies Unit, Royal Brompton Hospital, Fulham Road, London SW3 6HP, UK. t.hansel@ic.ac.uk

Current Allergy and Asthma Reports
|March 20, 2002
PubMed
Summary

New asthma therapies are urgently needed due to the global rise in disease burden. Current treatments are palliative, highlighting the need for novel drugs and disease-modifying immunotherapies to prevent asthma development.

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Area of Science:

  • Pulmonology
  • Pharmacology
  • Immunology

Background:

  • Asthma presents a growing global health challenge, necessitating innovative therapeutic strategies beyond current palliative treatments.
  • Existing inhaled bronchodilators and anti-inflammatory drugs require daily administration and have limited success in developing novel agents, with leukotriene antagonists being the only new class in 30 years.
  • Understanding asthma's underlying mechanisms and drug actions is crucial for rational therapeutic advancements.

Purpose of the Study:

  • To review the current landscape of asthma therapeutics and clinical development.
  • To identify unmet needs in asthma treatment, including severe and emergency cases.
  • To explore future directions in asthma therapy, such as disease-modifying immunotherapy.

Main Methods:

  • Literature review of current and developing asthma treatments.
  • Analysis of therapeutic targets including inflammation, cytokines, chemokines, and cell signaling pathways.
  • Examination of novel drug classes and immunotherapies in clinical development.

Main Results:

  • Numerous therapies targeting inflammation (eosinophils, IgE, cytokines, chemokines) and cell signaling are in clinical development.
  • Significant need exists for treatments for severe asthma uncontrolled by corticosteroids and for acute asthma emergencies.
  • Novel therapies are anticipated in the near future due to extensive pharmaceutical industry efforts.

Conclusions:

  • The development of novel asthma therapeutics is a priority, addressing the limitations of current palliative treatments.
  • Targeting specific inflammatory pathways and developing disease-modifying immunotherapies represent key future strategies.
  • An influx of new asthma treatments is expected, offering improved management and potential prevention.

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