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Related Experiment Video

Updated: Jul 7, 2026

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

Published on: November 7, 2015

Putting tumours in context.

M J Bissell¹, D Radisky

¹Division of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, California 99720, USA. mjbissell@lbl.gov

Nature Reviews. Cancer

|March 20, 2002

Summary

Cancer cells and their environment form a complex system that fuels tumor growth and evades immune responses. Understanding this tumor

Area of Science:

Oncology
Tumor Microenvironment
Cancer Biology

Background:

Tumor growth and immune evasion are influenced by interactions between cancer cells and their surrounding environment.
The tumor microenvironment (TME) plays a critical role in cancer progression and therapeutic resistance.

Purpose of the Study:

To investigate the functional association between cancer cells and their micro- and macroenvironment.
To explore how this interaction changes during malignancy progression.
To identify potential new therapeutic targets within the tumor ecosystem.

Main Methods:

The study likely involved analyzing the cellular and molecular components of the tumor microenvironment.
Methods may include in vivo and in vitro models, imaging techniques, and omics analyses to study cancer-environment interactions.

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1⁺ Tim-3⁺ CD8⁺ T Cells

Published on: February 8, 2018

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A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

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Published on: February 8, 2018

Main Results:

The research identified that the combined cancer cells and their environment act as a dynamic 'organ'.
This 'organ' actively promotes tumor progression and protects the tumor from immune system attacks.
The characteristics of this tumor 'organ' evolve as the cancer becomes more malignant.

Conclusions:

The tumor microenvironment is a critical determinant of cancer progression and immune escape.
Viewing the tumor and its environment as a functional 'organ' offers new perspectives on tumorigenesis.
Targeting the complex interactions within this tumor 'organ' may yield novel therapeutic strategies.