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The crystal structure of catechol oxidase: new insight into the function of type-3 copper proteins
Carsten Gerdemann1, Christoph Eicken, Bernt Krebs
1Institut für Anorganische und Analytische Chemie der Universität Münster, Wilhelm-Klemm-Strasse 8, 48149 Münster, Germany.
Accounts of Chemical Research
|March 20, 2002
Abstract:
The crystal structure of catechol oxidase reveals new insight into the functional properties of the type-3 copper proteins. This class of proteins includes the closely related and better-known tyrosinase as well as hemocyanin, an oxygen transport protein. All these proteins have a dinuclear copper center, have similar spectroscopic behaviors, and show close evolutionary and functional relationships. Comparison between the 3D structures of catechol oxidase and hemocyanins reveals the structural reasons for the divergence in function.