Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mouse lines differing in sensitivity to beta-CCM differ in tasks used for testing antidepressants.

Jean-Claude Do-Rego1, Charles Suaudeau, Georges Chapouthier

  • 1IFRMP 23, Unité de Neuropsychopharmacologie Expérimentale, CNRS UMR 6036, UFR de Médecine et Pharmacie, 22 Boulevard Gambetta, 76183 Rouen, France.

Pharmacology, Biochemistry, and Behavior
|March 20, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intestinal epithelial TLR4 knock out induces sex-specific effects on gut barrier and microbiome in an activity-based anorexia model.

Gut microbes·2026
Same author

[Cannabis also has epigenetic effects].

La Revue du praticien·2024
Same author

[Historical and philosophical issues in animal experimentation].

Biologie aujourd'hui·2023
Same author

[Not Available].

Bulletin de l'Academie nationale de medecine·2018
Same author

Correction for "Synthesis of Mixed Opioid Affinity Cyclic Endomorphin-2 Analogues with Fluorinated Phenylalanines".

ACS medicinal chemistry letters·2016
Same author

Opioid and Cannabinoid System in Food Intake.

Current pharmaceutical design·2016

Two mouse lines, selected for benzodiazepine (BZ) sensitivity (BS) or resistance (BR), show distinct anxiety behaviors. BS mice exhibit higher immobility in antidepressant tests, suggesting they are a valuable model for depression research.

Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Animal Models

Background:

  • Two mouse lines (BS and BR) were selectively bred for differential responses to benzodiazepine (BZ) receptor inverse agonists.
  • Previous studies indicated anxiety-related behavioral differences between these lines.

Purpose of the Study:

  • To extend the behavioral characterization of BS and BR mice.
  • To evaluate their utility as models for antidepressant drug testing.

Main Methods:

  • Locomotor activity was assessed.
  • Immobility was measured in the forced-swimming test (FST) and tail suspension test (TST).
  • The effect of imipramine on immobility was evaluated in the TST.

Main Results:

Related Experiment Videos

  • BR mice displayed lower locomotor activity than BS mice.
  • BS mice showed significantly longer immobility times in both FST and TST compared to BR mice.
  • Imipramine reduced immobility in BS mice but not in BR mice during the TST.

Conclusions:

  • BS mice exhibit behavioral patterns indicative of "depression" compared to BR mice.
  • These selectively bred mouse lines may serve as valuable models for investigating antidepressant mechanisms.
  • Further research can explore the neurochemical and neuroendocrine correlates of antidepressant action using these models.