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Gemcitabine-related pulmonary toxicity
1Department of Internal Medicine, Division of Oncology, University Hospital, Rämistrasse 100, CH-8091 Zurich, Switzerland.
Swiss Medical Weekly
|March 20, 2002
Abstract
Background:
Gemcitabine is an increasingly used and generally well tolerated anticancer drug. Rarely, it leads to potentially fatal pulmonary toxicity.
Case Descriptions And Results:
We describe the clinical features of 5 patients with gemcitabine-related pulmonary toxicity. Due to early diagnosis, prompt discontinuation of the drug, and treatment with steroids, toxicity was reversible in all cases.
Conclusion:
Early recognition of gemcitabine-related pulmonary toxicity is mandatory.