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Related Experiment Videos

Amino aciduria in weightlessness.

C S Leach1, P C Rambaut, N Di Ferrante

  • 1Lyndon B. Johnson Space Center, National Aeronautics and Space Administration, Houston, TX 77058, USA.

Acta Astronautica
|October 1, 1979
PubMed
Summary
This summary is machine-generated.

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Spaceflight alters amino acid metabolism, increasing urinary excretion during longer missions. Muscle and skeletal changes were also noted, suggesting impacts on protein synthesis.

Area of Science:

  • Space Medicine
  • Human Physiology
  • Biochemistry

Background:

  • Understanding the metabolic impact of spaceflight is crucial for astronaut health.
  • Previous studies have indicated potential physiological changes during prolonged space missions.

Purpose of the Study:

  • To investigate urinary amino acid excretion as a biomarker for metabolic effects of spaceflight.
  • To assess changes in muscle and skeletal metabolism during extended space missions.

Main Methods:

  • Analysis of urinary amino acid levels in Skylab crewmen over 28, 59, and 84-day flights.
  • Controlled dietary intake and complete urine collection were ensured for all participants.

Main Results:

  • Most amino acids showed increased urinary excretion during the first month of spaceflight.
Keywords:
NASA Experiment Number M073

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  • Elevated excretion levels persisted, though diminished, into the second and third months.
  • Evidence suggested alterations in muscle and skeletal metabolism.

    • Conclusions:

    • Urinary amino acid profiles serve as indicators of spaceflight-induced metabolic changes.
    • Further research is needed to identify additional markers for protein synthetic processes during spaceflight.