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Related Experiment Videos

Fractures in pediatric Ewing sarcoma.

L M Wagner1, M D Neel, A S Pappo

  • 1Department of Hematology/Oncology, University of Tennessee College of Medicine, Memphis, USA.

Journal of Pediatric Hematology/Oncology
|March 21, 2002
PubMed
Summary
This summary is machine-generated.

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Children with long-bone Ewing sarcoma family of tumors (ESFT) have a significant risk of fractures, particularly those with femoral tumors. Fractures after therapy may indicate recurrence or a new malignancy.

Area of Science:

  • Pediatric Oncology
  • Orthopedic Oncology
  • Skeletal Metastasis

Background:

  • Ewing sarcoma family of tumors (ESFT) can affect long bones in children.
  • Fractures are a potential complication in patients with bone tumors.

Purpose of the Study:

  • To investigate the incidence, timing, and clinical importance of long-bone fractures in pediatric patients diagnosed with ESFT.
  • To identify risk factors and patterns associated with fractures in long-bone ESFT.

Main Methods:

  • Retrospective review of 93 consecutive pediatric cases with long-bone ESFT.
  • Analysis of fracture occurrence in relation to tumor location, diagnosis, and treatment, including radiotherapy.

Main Results:

  • Fractures occurred in 15% (14/93) of patients with long-bone ESFT, most frequently in the femur.

Related Experiment Videos

  • Femoral ESFT patients had a 30% fracture incidence; tumors in the proximal femur showed a 50% fracture rate, often at diagnosis.
  • 64% of fractures occurred post-radiotherapy, with three linked to recurrence or secondary cancers.

    • Conclusions:

    • Patients with femoral ESFT face a high risk of fracture.
    • Fractures developing after therapy completion warrant suspicion for tumor recurrence or secondary malignancy.