Related Experiment Video
Updated: Aug 17, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Stability of sodium oxacillin in intravenous solutions
Abstract:
The influence of concentration, vehicle, dextrose and temperature on the stability of sodium oxacillin solutions was determined using a chemical kinetic approach. Sodium oxacillin degraded faster in dextrose solution than in sodium chloride injection. This finding was attributed to the catalytic effect of dextrose on sodium oxacillin hydrolysis. Solutions of 1-50 mg/ml oxacillin in each vehicle were found to be stable for 24 hours at 23 C. The degradation of sodium oxacillin in various dextrose solutions was independent of oxacillin concentration, and followed first order kinetics.
Related Concept Videos
Ionic Strength: Effects on Chemical Equilibria
In this solution, the primary cation—the calcium...
Solution Composition During Acid/Base Titrations
The α0 and α1 values represent the...
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
Dosage Interval and Administration Route: Determination Methods
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Estimation of k and VD of Aminoglycosides

