Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PPAR expression and function during vertebrate development.

Liliane Michalik1, Béatrice Desvergne, Christine Dreyer

  • 1Institut de Biologie Animale, Université de Lausanne, Switzerland.

The International Journal of Developmental Biology
|March 21, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Evaluation of hyperferitinemia].

Revue medicale suisse·2026
Same author

The emerging role of PPARs in primary biliary cholangitis.

Trends in molecular medicine·2026
Same author

Angptl4 integrates dietary and microbial signals to disrupt gut barrier function in MASH.

Nature communications·2026
Same author

Author Correction: The dynamics of mutational selection in cutaneous squamous carcinogenesis.

Communications biology·2026
Same author

Hepatic FGF21 is not required for fasting metabolism but guides protein appetite post energy depletion.

EMBO reports·2026
Same author

Obstetrical Impact of Anti-MUT (Anti-MNS35) Alloimmunization.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie·2026

Peroxisome proliferator activated receptors (PPARs) regulate gene expression in metabolic pathways. This review examines PPAR expression and roles in Xenopus and rodent development, focusing on epidermal differentiation.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • Peroxisome proliferator activated receptors (PPARs) are nuclear hormone receptors crucial for metabolic regulation.
  • PPARs bind to ligands and activate gene expression involved in various physiological processes.
  • Three isotypes (PPARalpha, PPARbeta, PPARgamma) exist, with evolutionary origins in metazoan development.

Purpose of the Study:

  • To review the expression patterns of PPARs during embryonic development in Xenopus laevis and rodents.
  • To explore the involvement of PPARs in key developmental processes, including tissue differentiation.
  • To highlight research on PPARalpha and PPARbeta in rodent epidermal differentiation.

Main Methods:

  • Literature review of studies on PPAR expression and function.

Related Experiment Videos

  • Analysis of gene expression data during embryonic development.
  • Examination of experimental evidence linking PPARs to differentiation processes.

    • Main Results:

    • PPARalpha and PPARbeta are broadly expressed in early Xenopus embryos, becoming restricted later.
    • Rodent PPAR isotypes exhibit distinct temporal and tissue-specific expression during development.
    • PPARs are implicated in the differentiation of adipose tissue, brain, placenta, and skin in rodents.

    Conclusions:

    • PPARs play significant roles in embryonic development and tissue differentiation across species.
    • PPARalpha and PPARbeta are particularly important for rodent epidermal development.
    • Understanding PPAR involvement offers insights into developmental biology and metabolic regulation.