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Reversible peripheral neuropathy in idiopathic hypoparathyroidism
1Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Acta Neurologica Scandinavica
|March 21, 2002
Summary
Idiopathic hypoparathyroidism can cause peripheral neuropathy. Treatment with calcium and vitamin D improved nerve function, showing calcium
Area of Science:
- Neurology
- Endocrinology
- Clinical Electrophysiology
Background:
- Idiopathic hypoparathyroidism is a rare endocrine disorder characterized by insufficient parathyroid hormone production.
- Hypocalcaemia, a common complication, can manifest with various neurological symptoms.
Observation:
- A 40-year-old male with idiopathic hypoparathyroidism presented with tetany, proximal weakness, and signs of hypocalcaemia.
- Electrophysiological studies revealed a predominantly axonal sensory-motor neuropathy with specific findings on median nerve conduction.
Findings:
- Peripheral neuropathy in hypocalcaemia is reversible with treatment.
- Normalization of calcium homeostasis led to progressive clinical and electrophysiological improvement in the patient's neuropathy.
Implications:
- This case highlights the critical role of calcium ion concentration in maintaining normal peripheral nerve function.
- The findings underscore the importance of early diagnosis and management of hypoparathyroidism to prevent or reverse neurological complications.