Menetrier's disease in a rhesus monkey (Macaca mulatta).

Area of Science:

• Veterinary Pathology
• Comparative Pathology

Background:

• Menetrier's disease is a rare disorder characterized by enlarged gastric rugae.
• Understanding animal models is crucial for studying human diseases.

Observation:

• A 20-month-old rhesus monkey presented with significant gastric mucosal changes.
• The monkey displayed enlarged rugae, a hallmark of Menetrier's disease.

Findings:

• Microscopic examination revealed mucosal hypertrophy and hyperplasia.
• Inflammatory cell infiltration, primarily lymphocytes and plasma cells, was noted in the mucosa and submucosa.
• Features closely mimicked human Menetrier's disease.

Implications:

• This rhesus monkey serves as a potential animal model for studying Menetrier's disease.
• Further research can explore the pathogenesis and treatment of this condition using this model.