Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Radiotherapy and cellular signalling.

C R Lewanski1, W J Gullick

  • 1Charing Cross Hospital, London, UK.

The Lancet. Oncology
|March 22, 2002
PubMed
Summary
This summary is machine-generated.

Recent advances reveal how cells sense and signal DNA damage from ionizing radiation. This review explores novel compounds and techniques to modulate cellular radiation responses, including apoptosis, cell-cycle arrest, and repair.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Production of antisera to synthetic peptides.

Methods in molecular biology (Clifton, N.J.)·2011
Same author

Characterization of the cell membrane-associated products of the Neuregulin 4 gene.

Oncogene·2007
Same author

Proteomic identification of secreted proteins as surrogate markers for signal transduction inhibitor activity.

British journal of cancer·2007
Same author

Mutations of the epidermal growth factor receptor in non-small cell lung cancer -- search and destroy.

European journal of cancer (Oxford, England : 1990)·2005
Same author

Clinical value of epidermal growth factor receptor expression in primary breast cancer.

Advances in anatomic pathology·2005
Same author

Consensus statement. Workshop on therapeutic resistance in breast cancer: impact of growth factor signalling pathways and implications for future treatment.

Endocrine-related cancer·2005

Area of Science:

  • Cellular and Molecular Biology
  • Radiation Biology
  • Biochemistry

Background:

  • Cellular responses to ionizing radiation involve complex signaling pathways.
  • These pathways recognize DNA and plasma membrane lipid damage.
  • Cellular outcomes include apoptosis, cell-cycle arrest, and DNA repair.

Purpose of the Study:

  • To review recent developments in understanding cellular responses to ionizing radiation.
  • To discuss novel compounds and techniques for manipulating these responses.
  • To highlight molecular targets involved in radiation modulation.

Main Methods:

  • Literature review of cellular and molecular biology studies.
  • Analysis of protein signaling systems in response to radiation.

Related Experiment Videos

  • Discussion of molecular targets and therapeutic strategies.

    • Main Results:

    • Identification of key signaling pathways activated by radiation damage.
    • Overview of molecular mechanisms controlling cellular responses.
    • Exploration of potential interventions to modulate radiation sensitivity.

    Conclusions:

    • Cellular response to radiation is a complex, multi-pathway process.
    • Targeting specific molecular pathways offers potential for modulating radiation effects.
    • New compounds and techniques show promise for enhancing or mitigating radiation responses.