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Related Experiment Videos

Informatic tools for proteome profiling.

Deb N Chakravarti1, Bulbul Chakravarti, Ioannis Moutsatsos

  • 1Biotechnology Discovery Research Group, Wyeth Lederle Vaccines, West Henrietta, NY 14586, USA. chakradn@war.wyeth.com

Biotechniques
|March 22, 2002
PubMed
Summary

Proteomics research in pharma and biotech is rapidly advancing with new applications. However, significant gaps exist in informatics and software tools for managing the vast data generated by these powerful techniques.

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Area of Science:

  • Biotechnology
  • Pharmaceutical Research
  • Proteomics

Background:

  • Proteomics research is increasingly vital in the pharmaceutical and biotechnology industries.
  • Applications span drug discovery, target identification, protein characterization, toxicology, and clinical research.
  • Novel applications are driving advancements in understanding drug mechanisms of action.

Purpose of the Study:

  • To survey available software and informatics tools for proteome profiling.
  • To highlight the challenges in managing the massive data generated by modern proteomics.
  • To discuss the importance of relational databases for protein identification data management.

Main Methods:

  • Utilizes two-dimensional gel electrophoresis.
  • Employs advanced mass spectrometry techniques.

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  • Integrates sequence database correlation for protein identification.

    • Main Results:

    • Identifies speed and accuracy in protein identification from complex mixtures.
    • Surveys current software and informatics tools for proteome profiling.
    • Highlights a disparity between technological adoption and informatics support.

    Conclusions:

    • Despite technological advancements, informatics and software tools lag behind the data generation capacity of proteomics.
    • Relational databases are crucial for effective management of protein identification data.
    • Addressing these informatics gaps is essential for the continued progress of proteomics in drug development and biotechnology.