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Retinoblastoma in older children
Zeynel A Karcioglu1, Emad B Abboud, Saleh A Al-Mesfer
1King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Summary
Retinoblastoma (RB) in older children often presents atypically. This study analyzed 18 patients over 5 years old, finding that clinical and histopathological features of RB were frequently unusual in this age group.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Pathology
Background:
- Retinoblastoma (RB) is the most common primary intraocular malignancy in children.
- RB typically affects infants and toddlers, but atypical presentations in older children are recognized.
Purpose of the Study:
- To review the clinical and histopathological features of retinoblastoma (RB) in children presenting after 5 years of age.
- To understand the atypical manifestations of RB in an older pediatric population.
Main Methods:
- Retrospective case series analysis of 337 consecutive retinoblastoma (RB) patients.
- Selection of 18 patients (5.3%) aged 5 years or older for detailed clinical and histopathological review.
Main Results:
- The study included 18 patients aged 5-12 years (mean 6.4 years).
- Unilateral disease occurred in 14 patients; bilateral in 4. Consanguinity was noted in 11 children.
- Presenting signs included leukocoria (7 patients), uveitis, cellulitis, or trauma; 3 patients had flat, plaque-like lesions on histopathology.
Conclusions:
- Atypical clinical features were observed in 47% of older pediatric retinoblastoma patients.
- Atypical histopathological features were present in 21% of these cases, highlighting diagnostic challenges.