Dural melanoma associated with ocular melanosis and multiple blue nevi

Area of Science:

• Neuro-oncology
• Dermatology
• Pathology

Background:

• Primary meningeal melanomas of the central nervous system (CNS) are rare, typically originating from leptomeninges.
• Primary dural melanomas are occasionally linked with Nevus of Ota.
• The association of primary dural melanoma with multiple cutaneous blue nevi is unprecedented.

Observation:

• A case report details a 41-year-old Asian woman with primary dural melanoma.
• The patient presented with ocular melanosis and multiple cutaneous blue nevi.
• The patient remains alive over 8 years post-tumor resection (subtotal and total).

Findings:

• This case highlights a novel association between primary dural melanoma, ocular melanosis, and multiple blue nevi.
• Prolonged survival was achieved through surgical intervention.
• Dural melanomas may exhibit a less aggressive clinical course compared to other CNS melanomas.

Implications:

• The coexistence of these conditions warrants further investigation into their shared etiology.
• Surgical extirpation appears to be a viable and effective treatment for primary dural melanoma.
• This case challenges the perception of CNS melanoma as uniformly aggressive, particularly for dural variants.