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[Griseofulvin].

M Develoux1

  • 1Service de Parasitologie-Mycologie, Hôpital Tenon, 4, rue de la Chine, 75020 Paris. michel.develoux@tnn.ap-hop-paris.fr

Annales De Dermatologie Et De Venereologie
|March 23, 2002
PubMed
Summary
This summary is machine-generated.

Griseofulvin, an early oral antifungal, treats dermatophytoses by inhibiting fungal growth, though its exact mechanism is unclear. It remains a primary choice for tinea capitis, especially in children, despite newer alternatives for other infections.

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Area of Science:

  • Mycology
  • Pharmacology
  • Dermatology

Context:

  • Griseofulvin is a long-standing oral antifungal agent derived from Penicillium species.
  • It was the first oral medication for dermatophytoses, used for over four decades.
  • Its antifungal properties are fungistatic, with proposed mechanisms including interference with mitosis and microtubule function.

Purpose:

  • To review the pharmacology, efficacy, and safety of griseofulvin in treating fungal infections.
  • To highlight its current role in dermatophyte treatment, particularly tinea capitis.
  • To discuss absorption, distribution, metabolism, excretion, and drug interactions.

Summary:

  • Griseofulvin absorption is enhanced by fatty meals, with peak plasma levels at 4 hours. It concentrates in the stratum corneum, with deposition in new cells potentially key for hair and nail penetration.

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  • While effective for tinea capitis (80-90% response rates), its use in onychomycosis yields disappointing results, with newer agents preferred for toenail infections.
  • Generally well-tolerated, especially in children, common side effects include GI upset and skin reactions. Significant drug interactions involve phenobarbital, anticoagulants, and oral contraceptives.

    • Impact:

    • Griseofulvin remains a valuable, well-tolerated treatment option for specific dermatophyte infections like tinea capitis in pediatric populations.
    • Understanding its pharmacokinetics and potential interactions is crucial for optimizing patient outcomes.
    • The review underscores the evolving landscape of antifungal therapy, with griseofulvin maintaining a niche role.