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Related Experiment Videos

Nitrofurantoin-induced chronic active hepatitis.

Guy Amit1, Patrizia Cohen, Zvi Ackerman

  • 1Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.

The Israel Medical Association Journal : IMAJ
|March 23, 2002
PubMed
Summary
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Nitrofurantoin can cause chronic active hepatitis, a serious liver injury. Discontinuation alone may not suffice; treatment with glucocorticoids is often necessary for recovery.

Area of Science:

  • Hepatology
  • Pharmacology
  • Immunology

Background:

  • Nitrofurantoin is a widely used urinary antiseptic.
  • Hepatic injury is a known, albeit uncommon, adverse effect of nitrofurantoin therapy.

Observation:

  • Three patients developed chronic active hepatitis following long-term nitrofurantoin use.
  • Discontinuation of nitrofurantoin alone did not resolve the liver injury.

Findings:

  • Treatment with glucocorticoids was necessary for remission.
  • One patient experienced fatal liver failure.
  • The study reviewed existing literature on nitrofurantoin-induced liver injury.

Implications:

  • Clinicians should exercise caution when prescribing nitrofurantoin, especially for extended periods.

Related Experiment Videos

  • Increased awareness of this potential idiosyncratic hepatotoxicity is vital.
  • The immune-mediated nature of this adverse drug reaction is increasingly recognized.