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Reductive amination products containing naphthalene and indole moieties bind to melanocortin receptors
Felikss Mutulis1, Ilze Mutule, Maris Lapins
1Department of Pharmaceutical Biosciences, Division of Pharmacology, Uppsala Biomedical Center, PO Box 591, Uppsala University, S-751 24 Uppsala, Sweden.
Bioorganic & Medicinal Chemistry Letters
|March 23, 2002
Abstract:
Presumed pharmacophoric groups of melanocortin peptides (naphthalene, amino or guanidine, and indole moieties) were combined in mimetics molecules looking for their favorable location for activity at melanocortin (MC) receptors. Twenty-two compounds were prepared and tested. The best of these displayed micromolar affinities for the MC receptors.