Related Experiment Videos
Thalidomide and its analogues as cyclooxygenase inhibitors
Tomomi Noguchi1, Rumiko Shimazawa, Kazuo Nagasawa
1Institute of Molecular & Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Bioorganic & Medicinal Chemistry Letters
|March 23, 2002
Abstract:
Thalidomide showed cyclooxygenase (COX)-1/2 inhibitory activity with a potency comparable to that of aspirin. Structural development studies of thalidomide resulted in potent COX-1/2 inhibitors, and COX-1-selective and COX-2-selective inhibitors.