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Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase
Patrizia Alberti1, Philippe Schmitt, Chi-Hung Nguyen
1Laboratoire de Biophysique, Muséum National d'Histoire Naturelle, INSERM U 201, CNRS UMR 8646, 43 rue Cuvier, 75231 Paris cedex 05, France.
Bioorganic & Medicinal Chemistry Letters
|March 23, 2002
Abstract:
Telomeric G-rich single-stranded DNA can adopt a G-tetraplex structure which has been shown to inhibit telomerase activity. We have examined benzoindoloquinolines derivatives for their ability to stabilize an intramolecular G-quadruplex. The increase in T(m) value of the G-quadruplex was associated with telomerase inhibition in vitro.