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The neurological examination: advancements in its quantification
Archives of Physical Medicine and Rehabilitation
|October 1, 1975
Summary
Researchers developed objective tests to quantify neurological functions for clinical neurology. These instrumented tests, including 57 detailed assessments, have been validated in trials for multiple sclerosis and Parkinson's disease.
Area of Science:
- Neurology
- Biomedical Engineering
- Biostatistics
Background:
- Current neurological assessments lack objective quantification.
- Need for standardized, measurable tools in clinical neurology.
- Existing objective tests require further development and validation.
Purpose of the Study:
- To present the development of objective tests for quantifying neurological functions.
- To describe the methodology for test administration and personnel training.
- To illustrate the application of these tests in clinical settings.
Main Methods:
- Development of instrumented tests for diverse neurological functions (cognition, motor skills, etc.).
- Extensive evaluation and validation in randomized double-blind trials.
- Focus on clinical quantitative neurological examination (CQNE) development.
Main Results:
- Successfully developed and validated a suite of objective neurological tests.
- Demonstrated utility in multiple sclerosis and Parkinson's disease clinical trials.
- Detailed description and illustration of 57 distinct tests.
Conclusions:
- The clinical quantitative neurological examination (CQNE) offers a novel approach to neurological assessment.
- These objective tests aim to fill a gap in current clinical neurology.
- The developed tests are ready for broader clinical application and further research.