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Intercellular adhesion molecule-1 gene polymorphisms in isolated polymyalgia rheumatica.
Mahsa M Amoli1, Emma Shelley, Derek L Mattey
1ARC Epidemiology Unit, Manchester University Medical School, United Kingdom.
The Journal of Rheumatology
|March 26, 2002
Summary
Intercellular adhesion molecule-1 (ICAM-1) gene variations do not directly impact polymyalgia rheumatica (PMR) severity. However, a specific ICAM-1 genotype combined with HLA-DRB1*0401 significantly increases the risk of PMR relapses.
Area of Science:
- Immunogenetics
- Rheumatology
Background:
- High levels of soluble intercellular adhesion molecule-1 (ICAM-1) are observed in untreated polymyalgia rheumatica (PMR).
- The role of ICAM-1 genetic variations in isolated PMR has not been fully elucidated.
Purpose of the Study:
- To investigate the clinical implications of ICAM-1 polymorphisms in isolated PMR.
- To examine the association between ICAM-1 gene variations and disease relapses in PMR patients.
Main Methods:
- Genotyping of 72 isolated PMR patients and 129 controls for HLA-DRB1 and ICAM-1 polymorphisms (codons 241 and 469).
- Molecular methods were employed for genotyping.
Main Results:
- No significant differences in ICAM-1 allele or genotype distribution were found between PMR patients and controls.
- ICAM-1 polymorphisms were not associated with disease relapses independently.
- Relapses were primarily linked to the HLA-DRB1*0401 allele (OR 7.2).
- A combination of HLA-DRB1*0401 and ICAM-1 codon 241 GG genotype significantly increased relapse risk (OR 15.2).
Conclusions:
- ICAM-1 polymorphisms alone are not associated with disease severity in isolated PMR.
- The co-occurrence of HLA-DRB1*0401 and ICAM-1 codon 241 GG homozygosity is significantly associated with an increased risk of relapses in PMR patients.