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[Meningococcus profilaxis (author's transl)].

E Pérez Trallero, E Pérez-Yarza, C Ruíz Benito

    Medicina Clinica
    |November 25, 1979
    PubMed
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    Most Neisseria meningitidis infections in San Sebastian were resistant to sulfonamide. However, no strains showed resistance to rifampin or minocycline, with children under four most affected.

    Area of Science:

    • Microbiology
    • Epidemiology
    • Infectious Diseases

    Background:

    • Neisseria meningitidis is a significant cause of bacterial meningitis and sepsis worldwide.
    • Antibiotic resistance in Neisseria meningitidis poses a growing public health concern.
    • Understanding local resistance patterns is crucial for effective treatment strategies.

    Purpose of the Study:

    • To investigate the antibiotic susceptibility patterns of Neisseria meningitidis isolates.
    • To identify the predominant serogroups and demographic distribution of meningococcal infections.
    • To assess resistance to sulfonamide, rifampin, and minocycline.

    Main Methods:

    • Disk diffusion method was employed to determine antibiotic susceptibility.
    • Susceptibility testing was performed using specific disk concentrations for sulfadiazine, rifampin, and tetracycline (minocycline).

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  • Serogrouping and demographic data were collected for all identified cases.

    • Main Results:

    • Out of 96 Neisseria meningitidis cases, a high prevalence of sulfonamide resistance was observed (all but 4 strains).
    • No resistance was detected against rifampin or minocycline among the isolated strains.
    • Serogroup B was the most common (67 isolates), followed by serogroup C (5 isolates) and serogroup A (1 isolate); 23 strains were not typed.
    • Children under four years old represented the most affected age group (67.7%).
    • The attack rate was slightly higher in males (52) than in females (44).

    Conclusions:

    • Sulfonamide resistance is widespread in Neisseria meningitidis in San Sebastian.
    • Rifampin and minocycline remain effective treatment options against circulating meningococcal strains.
    • Targeted surveillance and antibiotic stewardship are essential to monitor and manage antimicrobial resistance.