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Related Experiment Videos

MINT: a Molecular INTeraction database.

Andreas Zanzoni1, Luisa Montecchi-Palazzi, Michele Quondam

  • 1Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.

FEBS Letters
|March 26, 2002
PubMed
Summary
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The MINT database stores functional protein interactions from scientific literature. It includes direct and indirect interactions, kinetic data, and participating domains for comprehensive analysis.

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Computational Biology

Background:

  • Protein interaction data is crucial for understanding cellular processes.
  • Existing databases facilitate retrieval and analysis of large interaction datasets.
  • A need exists for comprehensive databases storing diverse functional protein interactions.

Purpose of the Study:

  • To introduce MINT (Molecular INTeraction database), a novel resource for storing functional protein-protein interactions.
  • To design MINT for cataloguing binary complexes and other functional interactions, including enzymatic modifications.
  • To focus on experimentally verified interactions, encompassing both direct and indirect relationships.

Main Methods:

  • MINT stores data on functional interactions between proteins, including binary complexes and enzymatic modifications.

Related Experiment Videos

  • The database includes information on kinetic and binding constants and participating domains when available.
  • Expert curators, assisted by the 'MINT Assistant' software, extract and curate interaction data from scientific literature.
  • The 'MINT Viewer' tool allows for graphical extraction and visualization of interaction data.

    • Main Results:

    • Release 1.0 of MINT contains 4568 experimentally verified protein-protein interactions.
    • Of these, 782 interactions are classified as indirect or genetic interactions.
    • MINT provides an exhaustive description of interactions, including kinetic and domain information.

    Conclusions:

    • MINT serves as a valuable, computer-readable resource for protein interaction information.
    • The database facilitates the retrieval and analysis of extensive protein interaction datasets.
    • MINT enhances the understanding of functional relationships between proteins through comprehensive data curation.