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Coronary endothelial dysfunction and myocardial cell damage in chronic stable idiopathic dilated cardiomyopathy
Vicens Martí1, Rosa Aymat, Manel Ballester
1Hemodynamic Unit, Hospital de la Santa Creu i Sant Pau, Sant Antoni M. Claret 167, 08025 Barcelona, Spain. 18461vmc@comb.es
Insights
Idiopathic dilated cardiomyopathy patients often have endothelial dysfunction and myocardial damage. Abnormal coronary vasomotor response correlates with increased antimyosin uptake, suggesting a link to heart muscle injury.
Area of Science:
- Cardiology
- Vascular Biology
- Biomedical Imaging
Background:
- Endothelial dysfunction, indicated by impaired endothelium-dependent vasodilatation, is a hallmark of cardiovascular disease.
- Indium-111 monoclonal antimyosin antibodies are used to detect myocardial cell damage.
- Idiopathic dilated cardiomyopathy (IDCM) is a significant cause of heart failure.
Purpose of the Study:
- To investigate the correlation between endothelial dysfunction and myocardial antimyosin uptake in patients with IDCM.
- To assess endothelial function using acetylcholine and quantify myocardial damage via antimyosin antibody uptake.
Main Methods:
- Twenty-two patients with chronic stable IDCM underwent intracoronary acetylcholine infusion to evaluate endothelial function.
- Coronary artery vasomotor responses were measured using quantitative coronary analysis.
- Myocardial antimyosin antibody uptake was quantified using the heart-to-lung ratio (HLR).
Main Results:
- Eighty-two percent of patients exhibited endothelial dysfunction.
- Eighty-two percent of patients showed abnormal antimyosin uptake.
- A significant correlation was found between coronary vasomotor response to acetylcholine and antimyosin antibody uptake intensity (r=-0.45, P<0.04).
Conclusions:
- A high prevalence of coronary endothelial dysfunction and myocardial antimyosin uptake exists in IDCM patients.
- The study suggests that abnormal coronary vasomotor response is linked to the extent of myocardial damage in IDCM.
Unlabelled:
Impairment of endothelium-dependent vasodilatation in response to acetylcholine reflects an abnormal endothelial function. Labelled indium-111 monoclonal antimyosin antibodies enable detection of myocardial cell damage. We analysed whether endothelial dysfunction correlates with myocardial antimyosin uptake in a selected group of patients with idiopathic dilated cardiomyopathy.
Methods:
Twenty-two consecutive patients with chronic stable idiopathic dilated cardiomyopathy (18 males and four females) were included. The duration of heart failure symptoms was 46+/-34 months. At inclusion, the functional class of New York Heart Association was 2.1+/-0.7. Endothelial function was evaluated using intracoronary graded concentrations of acetylcholine. Vasomotor responses of the left anterior descending coronary artery were measured by quantitative coronary analysis. Myocardial uptake of antimyosin antibodies was quantified by means of a heart-to-lung ratio (HLR).
Results:
Eighteen patients showed endothelial dysfunction (82%) and the remaining four patients showed a normal endothelial function. There were no statistically significant differences between patients with and without endothelial dysfunction in relation to clinical, echocardiographic and hemodynamic parameters. In addition, these variables did not correlate with the magnitude of the vasomotor response to acetylcholine. Eighteen patients (82%) showed abnormal antimyosin uptake; 15 of them (83%) showed endothelial dysfunction. The global mean HLR of antimyosin uptake was 1.73+/-0.24. The coronary vasomotor response to acetylcholine correlated with the intensity of uptake of antimyosin antibodies (r=-0.45, P<0.04).
Conclusions:
Coronary endothelial dysfunction and myocardial antimyosin uptake was found in a high percentage of patients with chronic stable idiopathic dilated cardiomyopathy. The abnormal vasomotor response seems to be related to the degree of myocardial damage.