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Effect of risperidone on serum cytokines.
1Department of Psychiatry, Holy Family Hospital, Catholic University of Korea, 420-717, 2 Sosa-Dong, Wonmi-Gu, Buchon City, Kyunggi Do, Korea. KDJ922@chollian.net
The International Journal of Neuroscience
|March 27, 2002
Summary
Risperidone treatment significantly increased Interleukin-12 (IL-12) plasma levels in schizophrenia patients. This finding suggests IL-12 may play a role in immune responses during antipsychotic therapy for schizophrenia.
Area of Science:
- Neuroimmunology
- Psychiatry
- Pharmacology
Background:
- Cytokine dysregulation is observed in schizophrenia.
- Antipsychotic medications can influence cytokine levels.
Purpose of the Study:
- To investigate the effect of risperidone on plasma cytokine levels in schizophrenia patients.
- To assess changes in Interleukin-1b (IL-1b), IL-2, IL-6, IL-12, and Interferon-gamma (INF-g) during acute illness and after 4 weeks of risperidone treatment.
Main Methods:
- Measured serum levels of IL-1b, IL-2, IL-6, IL-12, and INF-g in 19 schizophrenia patients.
- Assessed patient psychopathology using the Positive and Negative Syndrome Scale (PANSS).
- Compared cytokine levels before and after 4 weeks of risperidone treatment.
Main Results:
- Plasma IL-12 levels showed a significant increase after 4 weeks of risperidone treatment (p = .002).
- No significant changes were observed in IL-1b, IL-2, IL-6, and INF-g levels.
- No significant correlations were found between changes in cytokine levels and PANSS scores.
Conclusions:
- Increased IL-12 during risperidone treatment may indicate activation of immune responses.
- IL-12 might be important in the neuro-psychiatric immune response.