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Prediction of gene function in methylthioadenosine recycling from regulatory signals
Brooke A Murphy1, Frank J Grundy, Tina M Henkin
1Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA.
Journal of Bacteriology
|March 27, 2002
Abstract:
The S-box transcription termination control system, first identified in Bacillus subtilis, is used for regulation of gene expression in response to methionine availability. The presence of the S-box motif provided the first indication that the ykrTS and ykrWXYZ genes could play a role in recycling of 5'-methylthioadenosine, a by-product of polyamine biosynthesis that can be converted to methionine. In this study we demonstrate a role for the ykrTS and ykrWXYZ gene products in this pathway.