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Endometrial polyps with atypical (bizarre) stromal cells.
Lisa H Tai1, Fattaneh A Tavassoli
1Department of Gynecologic & Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA. tail@afip.osd.mil
The American Journal of Surgical Pathology
|March 27, 2002
Summary
Atypical stromal cells in the endometrium, often found in polyps, appear benign after surgical removal. Accurate identification is crucial to prevent overtreatment of this rare finding.
Area of Science:
- Gynecologic Pathology
- Endometrial Histopathology
Background:
- Atypical stromal cells are known in the lower female genital tract, primarily in polyps.
- Their occurrence in the endometrium is rare, with limited documentation.
Purpose of the Study:
- To describe a series of endometrial atypical stromal cell cases.
- To evaluate their clinical course and diagnostic considerations.
Main Methods:
- Retrospective review of 15 endometrial specimens with atypical stromal cells.
- Immunohistochemical studies for cell origin identification.
- Differential diagnosis including adenosarcoma and endometrial stromal sarcoma.
Main Results:
- 15 cases identified: 13 in endometrial polyps, 2 in stromal tissue.
- Patients aged 45-82 years.
- Benign clinical course observed after excision/polypectomy (1-44 months follow-up).
Conclusions:
- Endometrial atypical stromal cells, similar to those in other gynecologic sites, show a benign course post-excision.
- Distinguishing these from malignancy is vital to avoid overtreatment.
- Continued monitoring is recommended due to rarity and limited long-term data.