Related Experiment Videos
[Management of intermittent fever in the child]
1Service de pédiatrie Unité de médecine de l'adolescent Centre hospitalier intercommunal de Créteil 94010 Créteil. philippe.reinert@chicreteil.fr
Abstract:
Recurrent fevers in children are common, mainly due to viral (particularly in day care centers), or to bacterial (urinary tract upper and lower respiratory) infections. The diagnosis of recurrent hereditary fever is now possible on the basis of clinical features, biochemical and genetic tests. Familial Mediterranean Fever (FMF) remains the most frequent disorder of this group, which includes now three other entities: TNF receptor associated periodic syndrome (TRAPS), the hyperIgD syndrome(HIDS) and the Muckle-Wells syndrome.
Insights
Recurrent fevers in children often stem from infections but can indicate hereditary conditions. Diagnosing these rare periodic fever syndromes, like Familial Mediterranean Fever, is now possible through clinical, biochemical, and genetic testing.
Area of Science:
- Pediatrics
- Genetics
- Immunology
Context:
- Recurrent fevers are common in children, frequently caused by viral or bacterial infections.
- Distinguishing infectious causes from rare hereditary periodic fever syndromes is crucial for appropriate management.
Purpose:
- To highlight the diagnostic advancements in identifying recurrent hereditary fevers in children.
- To differentiate common infectious fevers from specific periodic fever syndromes.
Summary:
- Recurrent fevers in children can be due to infections or hereditary periodic fever syndromes.
- Familial Mediterranean Fever (FMF), TNF receptor associated periodic syndrome (TRAPS), hyperIgD syndrome (HIDS), and Muckle-Wells syndrome are key entities.
- Diagnosis now integrates clinical evaluation, biochemical markers, and genetic testing.
Impact:
- Enables earlier and more accurate diagnosis of rare genetic fever disorders.
- Improves patient outcomes by distinguishing from common infections.
- Advances understanding of autoinflammatory conditions in pediatric populations.