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Use of automated primary screening on liquid-based, thin-layer preparations
Pierre Vassilakos1, Solène Carrel, Patrick Petignat
1Institute of Pathology, Department of Gynecology and Obstetrics, University Hospitals, Geneva, Switzerland. vassilakospierre@swissonline.ch
Acta Cytologica
|March 29, 2002
Summary
The AutoPap System accurately detects cervical abnormalities on AutoCyte PREP slides, with high-grade squamous intraepithelial lesions (HSIL+) showing the highest instrument scores. This system demonstrates a high capability for cervical cancer screening.
Area of Science:
- Cytopathology
- Medical Device Technology
- Cervical Cancer Screening
Background:
- Liquid-based cytology preparations are widely used for cervical cancer screening.
- Automated systems aim to improve the efficiency and accuracy of slide screening.
Purpose of the Study:
- To assess the accuracy of the AutoPap System in screening AutoCyte PREP liquid-based, thin-layer preparations.
- To compare AutoPap System slide classification results with final cytologic diagnoses.
Main Methods:
- 9,665 AutoCyte PREP slides were screened to establish reference diagnoses.
- Slides were processed using the AutoPap System, generating ranking scores for review.
- Results were compared against the established reference cytologic diagnoses.
Main Results:
- 8,688 slides (90.8%) were qualified for scanning; 884 (9.2%) were excluded.
- 85.2% of high-grade squamous intraepithelial lesions and greater (HSIL+) were ranked in the first category.
- Using a cutoff of the 3rd rank or less, 84% of cervical abnormalities and 100% of HSIL+ were identified.
Conclusions:
- The AutoPap System shows high accuracy in detecting cervical abnormalities on AutoCyte PREP slides.
- Higher instrument scores were associated with HSIL+ detection.