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Related Experiment Video

Updated: Jul 10, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
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Published on: August 29, 2012

Immunisations in solid-organ transplant recipients.

Klaus Stark1, Matthias Günther, Christian Schönfeld

  • 1Institute of Tropical Medicine, Charité, Humboldt University, Berlin, Germany. starkk@rki.de

Lancet (London, England)
|March 29, 2002
PubMed
Summary
This summary is machine-generated.

Vaccinations significantly benefit solid-organ transplant recipients by preventing infections. Careful risk-benefit analysis ensures vaccine safety and effectiveness, minimizing adverse reactions like graft rejection.

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Area of Science:

  • Immunology
  • Transplant Medicine
  • Vaccinology

Background:

  • Solid-organ transplant recipients face heightened risks of infectious diseases, many preventable by vaccines.
  • Immunizations are crucial interventions for this vulnerable population.
  • Vaccine recommendations require balancing efficacy against potential adverse events, including graft rejection.

Purpose of the Study:

  • To review current data on immunizations in solid-organ transplant recipients.
  • To assess the immunogenicity and safety of vaccines in this group.
  • To identify factors influencing immune response and provide recommendations for vaccination schedules.

Main Methods:

  • Systematic review of studies on vaccine efficacy and safety in solid-organ transplant recipients.
  • Analysis of factors associated with suboptimal immune responses.
  • Evaluation of existing immunization guidelines.

Main Results:

  • Data on the immunogenicity and safety profiles of various vaccines were summarized.
  • Factors contributing to diminished vaccine responses were identified.
  • Evidence-based recommendations for immunization schemes were formulated.

Conclusions:

  • Immunizations are vital for solid-organ transplant recipients, but require careful consideration of risks and benefits.
  • Optimizing vaccine strategies can improve protection against preventable infections.
  • Further research may refine vaccination protocols for enhanced patient outcomes.