Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterizing the MRI signature of hippocampal sclerosis of aging.

Alzheimer's research & therapy·2026
Same author

An open, fully-processed data resource for studying mood and sleep variability in the developing brain.

Aperture neuro·2026
Same author

Clinicoanatomic localization of iron-rich gliosis in aphasic presentations of globular glial tauopathy.

Brain communications·2026
Same author

An imaging biomarker to detect non-glucogenic shift in brain energy metabolism in Alzheimer's disease.

Journal of translational medicine·2026
Same author

Age dependence of brain oxygen metabolism in adults assessed by 3D constrained quantitative BOLD MRI.

NeuroImage·2026
Same author

The PMADS Project: A Longitudinal Multimodal Cohort Study to Understand Risk for Perinatal Mood and Anxiety Disorders.

bioRxiv : the preprint server for biology·2026
Same journal

Dependence of the Extra-Cellular Diffusion Coefficient on the Fractions of Neurites and Cell Bodies in Gray Matter.

Magnetic resonance in medicine·2026
Same journal

Triple-Pulse <sup>23</sup>Na MRI Sequence (TriNa) for Simultaneous Acquisition of Spin-Density-Weighted and Fluid-Attenuated Images.

Magnetic resonance in medicine·2026
Same journal

Evaluation of Phantom Doping Materials in Quantitative Susceptibility Mapping.

Magnetic resonance in medicine·2026
Same journal

Design of an 8-Channel Transmit 32-Channel Receive 11.7T Head Coil and Evaluation of SNR Gains.

Magnetic resonance in medicine·2026
Same journal

The Potential for Absolute Temperature Imaging Based on Brain Metabolites Using an FID-Shifting Approach in Gradient Echo Planar Spectroscopic Imaging (GREPSI).

Magnetic resonance in medicine·2026
Same journal

Prospective Head Motion Correction in T1- and T2-Weighted Long Echo Train Sequences Using Servo Navigation.

Magnetic resonance in medicine·2026
See all related articles

Related Experiment Video

Updated: May 31, 2026

A Triple Primary Cell Culture Model of the Human Blood-Brain Barrier for Studying Ischemic Stroke In Vitro
11:06

A Triple Primary Cell Culture Model of the Human Blood-Brain Barrier for Studying Ischemic Stroke In Vitro

Published on: October 6, 2022

Multiple-TE Based Blood-Brain-Barrier Water Exchange Time Measurement Using a TE-Resolved 3D TSE Stack-Of-Spirals

Bo Li1, Yiran Li1, Xiao Liang1

  • 1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland, USA.

Magnetic Resonance in Medicine
|May 30, 2026
PubMed
Summary
This summary is machine-generated.

A new ASL sequence, TASL, eliminates blurring for better blood-brain barrier (BBB) water exchange time measurement. This advanced technique improves perfusion SNR and provides reliable quantification of cerebral perfusion and BBB permeability.

Keywords:
BBBTE‐resolved readoutmultiple‐TEpCASLspiral

More Related Videos

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction
10:17

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction

Published on: December 8, 2016

Related Experiment Videos

Last Updated: May 31, 2026

A Triple Primary Cell Culture Model of the Human Blood-Brain Barrier for Studying Ischemic Stroke In Vitro
11:06

A Triple Primary Cell Culture Model of the Human Blood-Brain Barrier for Studying Ischemic Stroke In Vitro

Published on: October 6, 2022

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction
10:17

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction

Published on: December 8, 2016

Area of Science:

  • Magnetic Resonance Imaging
  • Neuroimaging
  • Physiology

Background:

  • Arterial Spin Labeling (ASL) is crucial for non-invasive brain perfusion quantification.
  • Accurate measurement of blood-brain barrier (BBB) water exchange time is vital for diagnosing neurological disorders.
  • Conventional ASL methods can suffer from artifacts like slice-wise intensity modulation and blurring.

Purpose of the Study:

  • To develop a novel, blurring-free, TE-resolved ASL sequence (TASL) for precise BBB water exchange time measurement.
  • To enhance the accuracy and reliability of quantitative perfusion imaging.
  • To overcome limitations of existing multiple-TE (mTE) ASL sequences.

Main Methods:

  • A 3D TSE spiral-readout pCASL sequence was modified for TE-resolved acquisition.
  • In vivo experiments were conducted on healthy volunteers comparing TASL with conventional pCASL.
  • Quantitative parameters including CBF, ATT, ITT, and Texch were evaluated, along with perfusion SNR and reproducibility.

Main Results:

  • TASL effectively eliminated T2 decay-induced slice-wise intensity modulation and blurring, significantly improving whole-brain perfusion SNR.
  • Cerebral blood flow (CBF) and arterial transit time (ATT) estimates showed minimal differences (<1%) between TASL and conventional methods.
  • TASL yielded higher mean water exchange time (Texch; 18.2%) and intravoxel transit time (ITT; 9.05%) values, with excellent test-retest reproducibility (ICC > 0.86, wsCV < 8.38%).

Conclusions:

  • The developed TASL sequence successfully eliminates signal intensity modulation and blurring artifacts.
  • TASL provides densely sampled echo times (TE) crucial for accurate parametric fitting.
  • TASL represents a valuable tool for accurate and reliable quantification of cerebral perfusion and BBB permeability.