Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transcervical chorionic villus sampling in multiple pregnancies using a biopsy forceps.

Gemma Casals1, Antoni Borrell, Josep M Martínez

  • 1Prenatal Diagnosis Unit, Department of Obstetrics and Gynecology, Hospital Clínic, University of Barcelona Medical School, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.

Prenatal Diagnosis
|March 29, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical outcome and safety of amnioreduction in singleton pregnancies with severe polyhydramnios.

Fetal diagnosis and therapy·2026
Same author

Understanding the experience of women living with obesity and reproductive pathology.

Endocrinologia, diabetes y nutricion·2026
Same author

Time-course evolution of counterfactual thinking after early pregnancy loss.

Scientific reports·2026
Same author

Assessing Impulsivity in Adolescents: Psychometric Properties of the Spanish Short S-UPPS-P.

Psicothema·2026
Same author

Prenatal Use of Exome Sequencing and Chromosomal Microarray Analysis: Indications, Interpretation, and Gene Selection Strategies.

Diagnostics (Basel, Switzerland)·2026
Same author

First trimester prediction of gestational diabetes mellitus by machine learning in twin pregnancies.

Archives of gynecology and obstetrics·2026

Transcervical chorionic villus sampling (CVS) in multiple pregnancies improved in effectiveness and safety with experience. This prenatal diagnostic method enables earlier genetic insights, aiding in selective termination decisions for abnormal karyotypes.

Area of Science:

  • Reproductive Medicine
  • Prenatal Diagnostics
  • Genetics

Background:

  • Multiple pregnancies present unique challenges for prenatal genetic testing.
  • Chorionic villus sampling (CVS) is a common first-trimester prenatal diagnostic procedure.
  • Transcervical CVS offers a minimally invasive approach for genetic analysis.

Purpose of the Study:

  • To evaluate the effectiveness and safety of transcervical chorionic villus sampling (CVS) in multiple pregnancies.
  • To assess the impact of increasing operator experience on CVS outcomes.
  • To determine the utility of CVS for early prenatal genetic diagnosis in multifetal gestations.

Main Methods:

  • Retrospective analysis of 75 transcervical CVS procedures in 39 multiple pregnancies (January 1990-March 2000).

Related Experiment Videos

  • Comparison of outcomes between two experience periods: Period A (1990-1994) and Period B (1995-2000).
  • Evaluation of cytogenetic report acquisition, abnormal karyotype detection, and subsequent invasive procedures.

    • Main Results:

    • Cytogenetic report acquisition improved significantly from 73% (Period A) to 98% (Period B).
    • The need for post-CVS amniocentesis decreased from 38% to 10% with increasing experience.
    • Spontaneous fetal loss rates before 20 weeks decreased from 8.7% to 3.3%, with a 3.3% loss rate after 20 weeks in Period B.

    Conclusions:

    • Increasing experience enhances the safety and effectiveness of transcervical CVS in multiple pregnancies.
    • Transcervical CVS facilitates early prenatal genetic diagnosis, crucial for informed decisions regarding selective termination.
    • This procedure supports safer management of abnormal karyotypes in multifetal gestations.