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Deglycobleomycin: solid-phase synthesis and DNA cleavage by the resin-bound ligand
Kenneth L Smith1, Zhi-Fu Tao, Shigeki Hashimoto
1Departments of Chemistry and Biology, University of Virginia, Charlottesville, Virginia 22901, USA.
Organic Letters
|April 2, 2002
Abstract:
[structure: see text] A greatly improved solid-phase synthesis of deglycobleomycin using a Dde-based linker is reported. The resin-bound deglycobleomycin could be completely deblocked and assayed for DNA plasmid relaxation, sequence-selective DNA cleavage, and light production from a molecular beacon.