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Fast dispersible ibuprofen tablets.

Simone Schiermeier1, Peter Christian Schmidt

  • 1Department of Pharmaceutical Technology, Eberhard-Karls-University Tübingen, Auf der Morgenstelle 8, 72076, Germany.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|March 30, 2002
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Summary
This summary is machine-generated.

Fast dispersible tablets were developed using direct compression, offering rapid disintegration in water or mouth. Optimized formulations achieved acceptable hardness and quick wetting times for improved patient compliance.

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems

Background:

  • Fast dispersible tablets (FDTs) offer convenient administration, disintegrating rapidly in water or orally.
  • Direct compression is a viable method for producing FDTs with high-dose drugs like ibuprofen.

Purpose of the Study:

  • To develop and characterize two types of fast dispersible tablets: water-dispersible and oro-dispersible.
  • To optimize oro-dispersible tablet formulations using a rotatable central composite design.

Main Methods:

  • Direct compression was used to prepare tablets containing coated ibuprofen.
  • Properties investigated included porosity, hardness, disintegration time, and viscosity.
  • A wetting test was developed and applied for oro-dispersible tablet evaluation.

Main Results:

  • A water-dispersible formulation with 26% galactomannan and 5% crospovidone disintegrated in 40s with 95N crushing strength.
  • An optimized oro-dispersible formulation (34% mannitol, 13% crospovidone) showed a 17s wetting time and 40N crushing strength.
  • Formulations demonstrated acceptable hardness and taste.

Conclusions:

  • Fast dispersible tablets can be successfully prepared via direct compression.
  • Optimized formulations meet criteria for both water-dispersible and oro-dispersible applications.
  • The developed wetting test is a suitable alternative for evaluating oro-dispersible tablets.