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Related Experiment Videos

Damage control: a guide to dealing with an infectious break.

S H Weisbroth1, S H Weisbroth

  • 1Taconic Anmed, 7642 Standish Place, Rockville MD 20855, USA. twoweis@erols.com

Lab Animal
|March 30, 2002
PubMed
Summary

Maintaining microbial stability in laboratory animals is crucial for research integrity. This study outlines a strategic sequence for managing infectious outbreaks, from detection to resolution.

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Area of Science:

  • Veterinary Medicine
  • Laboratory Animal Science
  • Research Management

Background:

  • Microbial status disruptions in laboratory animals can significantly impede research continuity.
  • Maintaining a controlled environment is essential for reproducible scientific outcomes.
  • Infectious breaks pose a substantial risk to research integrity and animal welfare.

Purpose of the Study:

  • To propose a structured approach for managing microbial status changes in research animal facilities.
  • To detail a sequence of actions for investigating and controlling infectious outbreaks.
  • To minimize research disruptions caused by microbial contamination events.

Main Methods:

  • Review of established protocols for managing infectious disease outbreaks in animal facilities.
  • Development of a sequential framework for response and control.
  • Case study analysis of potential infectious "break" scenarios.

Main Results:

  • A defined sequence of events for addressing microbial status changes was identified.
  • The framework covers detection, investigation, source identification, and control measures.
  • Proactive management strategies can mitigate research impact.

Conclusions:

  • A systematic approach to managing infectious breaks is vital for research continuity.
  • Effective investigation and control protocols are necessary to maintain animal model integrity.
  • Implementing a clear response sequence enhances laboratory animal facility management.

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